I've just updated to the latest build ((v23.0.1.0 64-bit) with a fresh install. I did not let the installer pull in any previous version's information (renamed the old config directory). I then attempted to install the latest hot-fix (hotfix_se2300_3_cumulative). SE locks at that point using 100% of a single CPU core. After several minutes I killed the application, deleted the config directory, and tried again. Same result.
SlickEdit Pro 2018 (v23.0.1.0 64-bit)
Build Date: February 14, 2019
Emulation: CUA
OS: Windows 10 x64
OS Version: 10.00.0
Memory: 10% Load, 6994MB/65465MB Physical, 9368MB/75193MB Page File, 4505MB/134217727MB Virtual
Shell Information: C:\WINDOWS\system32\cmd.exe /q
Screen Size: 3691 x 2160, 3840 x 2160
Installation Directory: C:\Program Files\SlickEdit Pro 23.0.1\ (non-removable drive,NTFS,453962MB free)
Configuration Directory: C:\Users\brent\Documents\My SlickEdit Config\23.0.1\ (non-removable drive,NTFS,453962MB free)