There should be some visual cue on the slickedit window to indicate which instance of the editor it is.
The first instance is special because when you run "vs somefile.txt" from the command line it always sends the file to the 1st instance.
If each instance was numbered, and that number showed in the title bar it would be helpful.
Also, "vs.exe" could have a new argument: -instanceIndex
to allow directing commands at additional instances.
(Ideally, vs.exe would allow the user to provider a specific name when creating an instance, instead of a simple incrementing index number).