From my (limited) experience with multiple monitors and everything I've ever read on this issue, it is a bad idea to put monitor 2 to the left of monitor 1 because of the way the pixel coordinates are defined (the origin is at the upper left of monitor 1 and negative coordinates can cause a lot of applications to get confused -- not necessarily because of the application, but because of the APIs they have to use to address the displays). To be fair, I'm not sure this is strictly a Windows issue.
Anyway, I'd recommend putting the #2 monitor on the right of #1.
My 2 cents.
Regards
Les