Yes, there is a way.  On the SlickEdit command-line, enter the command vcproj_debug_options.  There is a screenshot of this in the SlickEdit Help, in the Using WinDbg section.  Command-line parameters can be added on the executable name for any or all Configurations. You need to specify the executable name, but you can use the alias %o like you can on the Project Properties command-line for output file.  Something like this:
Executable Name:  "%o" arg1 arg2 arg3
Symbols Path can be left empty if your symbols are already being picked up by the compiler debugger.