I've noticed the same thing with recent updates. I've removed key bindings on Ctrl+O for gui-open and Ctrl+M for project-build, but they come back whenever I upgrade.
SlickEdit 2012 (v17.0.1.0 64-bit)
Serial number: WB824242
Licensed number of users: Single user
License file: C:\ProgramData\slickedit\17\slickedit.lic
Build Date: July 11, 2012
Emulation: Epsilon
OS: Windows 7 x64
OS Version: 6.01.7601 Service Pack 1
Memory: 43% Load, 5400MB/12278MB Physical, 4786MB/12277MB Page File, 396MB/8388607MB Virtual
Shell Info: c:\tccle11\tcc.exe
Screen Size: 1920 x 1200, 1200 x 1600
Project Type: Cpp
Language: .cpp (C/C++)
Installation Directory: C:\Program Files\SlickEditV17.0.1 x64\ (non-removable drive,NTFS,129498MB free)
Configuration Directory: C:\Users\Evan\Documents\My SlickEdit Config\17.0.1\ (non-removable drive,NTFS,129498MB free)
Spill File: c:\temp\$slk.9 (non-removable drive,NTFS,129498MB free)