High contrast is honored - But note that menu/window color changes are applied immediately but pop-up menus and the docked/sidebars require SE to be restarted to be applied.
Yeah it's a custom theme, but I just did a quick check: Control Panel | Appearance and Personalization | Personalization | Window Color | Advanced Appearance Settings:
the menu font colors in SE honor the windows appearances Menu Item font color. (the top menu bar)
The MDI windows tab in SE don't honor the windows title bar colors but the Window Item's text color (the text for the window contents)
The pop-up menu (right click on text window) is fixed at black but, ironically, the shortcut key text on the pop-up menu honors the pop-up menu color.
The docked/hidden sidebars are also fixed at dark gray.
Would it be possible to have the pop-up menu and the docked/hidden sidebars just follow the menu color for windows?