Unfortunately we don't currently have any type of listener for changing perspectives in Eclipse, so there's nothing I can really come up with right now that will be done automatically for you. I can provide you with a somewhat hacky SlickC command which toggles between the standard Eclipse debug key bindings, and the default Brief key bindings for those same keys.
I didn't want to just change the emulation from Brief to Eclipse and back, because there are side effects of changing emulations in SlickEdit that you would most likely not want to keep happening.
If you save and load the attached test.e file (Macro > Load Module, browse to test.e) you can use the command toggle_debug_bindings to toggle the key bindings. You can rename the command if you want. You can bind the command to a key (just don't make it one of the affected key bindings in the command) so that you can quickly switch back and forth when debugging. One thing to note is that the command cues off of the binding for F5, so if you have changed that binding from the default command for F5 in Brief (gui_find), you'll have to alter the macro slightly to get this to work.
Let me know if it works for you, and if you have any questions. Hope this helps.
- Ryan