My normal workflow is to have a LOT of files open. The code I work with tends to require that I be looking in a bunch of different places over the course of a day. I have a dozen or several dozen files open and arranged "willy-nilly" all over the available screen space.
The latest (non-beta) Mac SlickEdit has a problem which seems to be that it is continuously updating each of those windows, pegging the CPU at 100% even when I have not touched the keyboard for several minutes. Mouse clicks don't register and often keystrokes don't either - or they take tens of seconds to catch up to my typing. I abandoned the product and returned to using the Windows 7 laptop for coding.
I also prefer to use multiple screens, whereas SlickEdit puts everything inside its one window. That's the piece of my workflow which I missed from XEmacs. Because I prefer to have so many files visible for editing, I prefer to use all the screen real estate available.
With the beta release, I find that I can open a file and immediately float it. Any files which I open-by-reference (meaning Ctrl+, to go to the definition of a symbol) open in the same window as a new tab. I'm still getting used to this arrangement, but so far I like it. I've got editing windows all over the place, some with multiple tabs, some not.
The "base" window is, in effect, just another floating window. I have the "open" and "project" tabs sitting there, with some free space to their right. When I open a new file, it appears squeezed into that space to the right. Right click on its title tab, choose Float, and I'm happy.
As I type this, SlickEdit is idle but using 15% of one cpu. That's fine - it's responsive as I would expect. It's being pegged at 100% continuously that was the problem, so it's looking to me like that problem is solved.